I think you should address the time off in yourcover letter because employers will be wondering about what you've been doingfor the past two years. Do you have other activities you can use to cover the timeperiod in your resume? Examples include volunteer work, continuing education(courses, seminars, conferences, anything career related), freelance projects,etc.

Here's an article on the topic that might be helpful:

ResumeTips for Full-Time Parents Returning to Work

Good luck,
Kim Isaacs
The Resume Expert